Genesis 25:21-26

21And Isaac prayed to the Lord for his wife, because she was barren. And the Lord granted his prayer, and Rebekah his wife conceived.

22The children struggled together within her, and she said, "If it is thus, why is this happening to me?" So she went to inquire of the Lord.

23And the Lord said to her, "Two nations are in your womb, and two peoples from within you shall be divided; the one shall be stronger than the other, the older shall serve the younger."

24When her days to give birth were completed, behold, there were twins in her womb.

25The first came out red, all his body like a hairy cloak, so they called his name Esau.

26Afterward his brother came out with his hand holding Esau's heel, so his name was called Jacob. Isaac was sixty years old when she bore them.