Genesis 25:23-26

23And the Lord said to her: Two nations are in your womb; two peoples will come from you and be separated. One people will be stronger than the other, and the older will serve the younger.

24When her time came to give birth, there were indeed twins in her womb.

25The first one came out red-looking, covered with hair like a fur coat, and they named him Esau.

26After this, his brother came out grasping Esau’s heel with his hand. So he was named Jacob. Isaac was sixty years old when they were born.